DOI: 10.21276/ajptr
Thu, 23 May 2019

Synthesis of Some New 1, 2, 4 – Triazolo [3, 4-B] [1, 3, 4] Thiadiazole Derivatives As Possible Antitubercular Agents

P. Devi1*, P. Lekha1, R. Vijayaraj 2, V. Sekar1, R. Sambathkumar1

1.Department of Pharmaceutical Analysis, J.K.K.Nattraja College of Pharmacy, Kumarapalayam-638183, Namakkal, Tamilnadu.

2.Department of Pharmaceutical Chemistry, SRIPMS College of Pharmacy, Coimbatore, Tamilnadu.


ABSTRACT

In attempt to make significant pharmacologically active molecule, we report here the synthesis and in vitro antimicrobial activity of various series of 3 – (4 – fluorophenyl) - 6 – substituted phenyl [1, 2, 4] triazolo [3, 4 – b] [1, 3, 4] thiadiazole derivatives was prepared by the reaction of carbon di sulfide, hydrazine hydrate. The compounds have been prepared by using P-toluene sulphonic acid, dimethyl formamide, 4-fluoro benzaldehyde, substituted benzaldehyde under conventional and microwave method. The products were found to be solid. The six compounds are characterized by analytical UV, IR, Mass, NMR. The compounds were screened for antitubercular activity against Mycobacterium tuberculosis species by using alamar blue assay method.

Keywords: Carbon disulfide, hydrazine hydrate, microwave oven, anti tubercular activity

 


[PDF]   Viewed: 88   Downloaded: 41 DOI No: 10.21276/ajptr.2018.08.06.08
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