DOI: 10.21276/ajptr
Fri, 22 Mar 2019

Synthesis and Evaluation of 4-(2-Chloroquinolin-3-Yl)-6-(6-Methyl-1H-Benzimidazol-2-Yl)Pyrimidin-2-Amines as Potent Anthelmintic Agents

B. Shivakumar*, Indira. M. Madawali, Shivakumar Hugar and Navanath. V. Kalyane

Department of Pharmaceutical Chemistry, B.L.D.E.A’s SSM College of Pharmacy and Research Centre, Vijayapur, Karnataka-586103, India.


ABSTRACT

A new series of 4-(2-chloroquinolin-3-yl)-6-(6-methyl-1H-benzimidazol-2-yl)pyrimidin-2-amine (Va-k) have been synthesized by the reaction of 3-(2-chloroquinolin-3-yl)-1-(6-methyl-1H-benzimidazol-2-yl)prop-2-en-1-one (IVa-k) with guanidine nitrate in ethanol and aqueous solution of sodium hydroxide. The synthesized compounds were characterized by their IR, 1H NMR and Mass spectral studies. The synthesized compounds were evaluated for anthelmintic activity by in-vitro method, against south Indian adult earth worms Pheretima posthuma using Albendazole as a standard drug. Results of the activities reveal that, compounds exhibited moderate to good anthelmintic activity.

Keywords: 6-Methylbenzimidazoles, Chalcones, Pyrimidines, Albendazole, Anthelmintic activity.

 


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