DOI: 10.21276/ajptr
Sun, 23 Sep 2018

A Comparative Study On Antidiabetic Effects Of Ethanol Extract Of Origanum majorana And Indigofera Linnaei Ali On Streptozotocin Induced Diabetic Rats

Bimala Tripathy1*, S.Satyanarayana2, K.Abedulla Khan3, K.Raja4

1.Department of pharmacology, St. Mary’s Pharmacy College, Deshmukhi (V), Near Ramoji Film city, Greater Hyderabad - 508284, Telengana, India.

2.Department of pharmacology, Professor, Avanthi Institute of Pharmaceutical Sciences, Vizianagaram, Andhra Pradesh, India.

3.Department of clinical Pharmacy and Pharmacology, IBN SINA NATIONAL COLLEGE FOR MEDICAL STUDIES, Al Mahjar, Jeddah-22421, K.S.A.

4 Executive, Microbiology-QC, M/s Jodas Expoim Private Ltd, Hyderabad, India.


ABSTRACT

The evaluation of plant products on the basis of medicinal and therapeutic properties forms a platform for the discovery of newer drug molecules from different plant sources. To compare anti-diabetic effect between two ethanolic extracts of selected plants locally available in Bobbili region, Vizianagaram district, Andhra Pradesh, India on Streptozotocin induced diabetic rats. To compare anti-diabetic study, experimental rats were divided into five groups viz. Group I (Control), Group II (Diabetic, Streptozotocin, 50mg/kg bwt, i.p.), Group III (Diabetic with Glibenclamide(4mg/kg)), Group IV (Diabetic with Origanum majorana) and Group V (Diabetic with Indigofera linnaei Ali). Both plants extracts were supplemented with same dose i.e. 100mg/kg b.wt, orally. The blood glucose levels, lipid profile, body weight were evaluated in all above experimental groups before and after diabetes induction in 21 days pharmacological evaluation. Significantly decreased blood glucose level and simultaneously improved lipid profile and body weight in Group IV rats after oral administration of ethanol extract whereas in Group V rats are showing less effect compare to Group IV rats. Both the plant extracts effect compare with Group II and Group III rats statistically. Origanum majorana shows better antidiabetic activity because the leaf contain huge amount of antidiabetic phytoconstituents like rutin and quercetin flavonoids. In Indigofera linnaei Ali whole plant ethanol extract also shows antidiabetic activity because it contains kaempferol like important antidiabetic active constituents. Origanum majorana and Indigofera linnaei Ali plants may be used as a dietary supplement in diabetic patients. Further study is required to evaluate the antidiabetic activity.

Keywords: Origanum majorana, Indigofera linnaei Ali, Diabetes, Phytoconstituents

 


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