DOI: 10.21276/ajptr
Fri, 16 Nov 2018

Synthesis, Spectral Analysis and Anticancer Evaluation of Novel Pyrazoline Derivatives

Sagar A .Jadhav1*, P.J. Shirote1,  Kiran.M.Kulkarni1, Vipul.M.Patil2

1.Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra , India

2.Department of Pharmaceutical Chemistry , Ashokrao Mane College of Pharmacy, Peth Vadgaon, Kolhapur,  Maharashtra , India


ABSTRACT

The novel Pyrazoline derivatives were prepared  by cyclisation of substituted chalcone derivatives in the presence of 2, 4 dintro phenyl hydrazine hydrate. Structural elucidation of all synthesized  derivatives were done by spectral analysis ( IR , NMR and Mass spectroscopy). All synthesized derivatives  screened for their anticancer activities by MTT assay and  these prepared derivatives exhibits promising anticancer activities.

Keywords:  Chalcones , 2,4 dinitro phenyl hydrazine hydrate , spectral analysis , anticancer activity , MTT assay.

 


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