DOI: 10.21276/ajptr
Mon, 17 Dec 2018

A Review of Antibiotics Management of Chronic Prostatitis / Chronic Pelvic Pain Syndrome

Neethu J* ,Manuja VS1 ,Anjaly S Kumar1, Nithika Chacko1 ,Rengith Raj1

Sree Krishna, College of Pharmacy and Research Centre ,Thiruvanathapuram


ABSTRACT

Prostatitis is the inflammation of the prostate gland can be due to an infection as well as other various causes. Prostatitis is a common condition, with 35- 50 % of men affected with symptoms associated with Prostitis during their lifetime. Prostatitis can be caused by bacteria that leak into the prostate gland from the urinary tract. It can also caused by sexually transmitted organism such as Neisseriagonorrhoeae Chlamydiatrachomatis, HIV, Escherichia coli. According to National Institute Of Health Chronic Prostatitis Symptoms (NIH-CPSI) Prostatitis is of three types, Acute bacterial prostatitis, Chronic bacterial prostatitis, Chronic prostatitis /chronic pelvic pain syndrome, A symptomatic inflammation prostatitis .Chronic prostatitis /chronic pelvic pain syndrome is the common condition and most cases of prostatitis fall into this category. Traditionally, Chronic prostatitis /chronic pelvis pain syndrome in men was believed to be related to inflammation (usually secondary to infection) localized to the prostate [1]. Management of chronic prostatitis/chronic pelvic pain syndrome consisted of antibiotics and anti inflammatory and, later α-blockers and 5 -reductase inhibitors.α-Blockers, antibiotics and combination of these therapies provide greatest improvement in treatment of chronic prostatitis/chronic pelvis pain syndrome. Chronic prostatitis is not a single condition, but a term that is loosely used to describe a group of conditions causing genito –pelvic pain and urinary dysfunction in adult men [10].Both chronic prostatitis and the chronic pelvis pain syndrome is associated with abnormalities in semen and infertility and also result in the reduction in the quality of the life. Prostatitis tissues are best penetrated by drugs with a high pKa and high lipid solubility, such as quinolones ,macrolides ,tetracyclines and sulfa drugs [3]. Antibiotic therapy is recommended for acute exacerbation of chronic prostatitis, chronic bacterial prostatitis and chronic inflammatory prostatitis, if there is clinical, bacteriological or supporting immunological evidence of prostate infection[9]. Antibiotics treatment should be stopped if there is no improvement in symptoms. Many patients  with category III prostatitis will improve with antibiotic therapy.

Keywords: Chronic prostatitis/chronic pelvic pain syndrome, management, antibiotics therapy

 


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