DOI: 10.21276/ajptr
Sat, 18 Aug 2018

Ion-Pair Complex Method for the Spectrophotometric Determination of Tamsulosin In the Presence of Dutasteride by using Bromo Thymol Blue

I. Lakshmi Prasanna*1, G.T. Naidu1, Nuzhath Fathima2, I.E.Chakravarthy2 and G.Abdul Huq3

1. Department of Physics, Rayalaseema University, Kurnool.518007, AP.

2. Department of Chemistry, Rayalaseema University, Kurnool.518007, AP

3. Department of Chemistry, School of Sciences, Maulana Azad National Urdu University, Hyderabad, 500032, TS.


ABSTRACT

A simple, rapid, sensitive, accurate, precise spectrophotometric method has been developed for the estimation of Tamsulosin in the presence of Dutasteride  in pharmaceutical formulations. During the course of study, it is observed that acidic solution of the drug formed colored ion-association complexes with Bromo Thymol Blue (BTB) which is soluble in methanol. This property of the drug was followed for the development of spectrophotometric method for analysis of drug. The complex of Tamsulosin in the presence of Dutasteride with Bromo Thymol Blue showed λmax at 430 nm. The linearity range for Tamsulosin in the presence of Dutasteride was 10 µg/ml to 250 µg/ml. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The molar absorptivity and the sandell sensitivity of the method are found to be 6.6123×104 lit/mole/cm and 0.0067 µg/ml/cm2 respectively. 

Keywords: Spectrophotometry, Tamsulosin, Dutasteride, Ion-pair complex, Bromo Thymol Blue, Pharmaceutical formulations.

 


[PDF]   Viewed: 73   Downloaded: 47 DOI No: 10.21276/ajptr.2018.08.03.18
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter