DOI: 10.21276/ajptr
Mon, 27 May 2019

Study of Effect of Methanolic Extract of Thevetia Peruviana Leaves on Doxorubicin Induced Cardio Toxicity in Wistar Rats

Sk. Samiya*1, Y. Anil kumar 2, D. Brahmasrinivasarao3

1.B-Pharmacy, Department of Pharmacology, Hindu college of pharmacy, Guntur.

2. Assistant professor, Department of Pharmacology, Hindu college of pharmacy, Guntur.

3. Head of the Department, Department of Pharmacology, Hindu college of Pharmacy, Guntur.


Doxorubicin is an anthracycline antibiotic widely used as a chemotherapeutic agent in the treatment of several tumors. However, its cardiac toxicity limits its use at maximum therapeutic doses. Most studies implicated increased oxidative stress as the major determinant of DOX cardiotoxicity. Thevetia peruviana known to have antioxidant activity. The aim of the current study was to explore the potential protective effects of methanolic extract of Thevetia peruviana against DOX-induced cardiotoxicity in rats. Methanolic extract of this plant showed significant cardioprotective effect by lowering the serum levels of various biochemical parameters like Creatinine  phosphokinase (CPK), Lactate dehydrogenase (LDH), Alanine transaminase (ALT) and Aspartate transaminase (AST) in the selected model. Additionally, histopathological examination indicated a protection against DOX-induced cardiotoxicity. The results also suggests that the biologically active phytoconstituents such as flavonoids, alkaloids, glycosides, carbohydrates, triterpenoids and tannins present in the methanolic extract of plant which is confirmed from the qualitative analysis may be responsible for the significant cardioprotective activity.

Keywords: Thevetia peruviana, Cardioprotective activity, Doxorubicin, Cardiotoxicity.


[PDF]   Viewed: 146   Downloaded: 72 DOI No: 10.21276/ajptr.2018.08.05.07
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter