DOI: 10.21276/ajptr
Thu, 18 Oct 2018

Development and In Vivo Evaluation of Mouth Dissolving Films Containing Rasagiline

P. Srinivasa Rao1*, T. Rama Mohan Reddy2

1Research Scholar, Mewar University, Chittorgarh, Rajasthan, India

2Research Supervisor, Mewar University, Chittorgarh, Rajasthan, India


ABSTRACT

The aim of present investigation was to formulate the fast dissolving oral films (FDOF) of Rasagiline, an anti-Parkinson drug. Rasagiline fast dissolving films were formulated by solvent casting method containing HPMC 5cps, 15cps and 50cps as polymers and PEG 400 as plasticizer, Crospovidone and SSG as superdisintigrating agents. All films prepared were smooth and elegant in appearance and showed no visible cracks, even in weight, thickness and drug content. Formulation F16 was considered as the optimized formulation as it showed the faster disintegration time i.e., 8 sec, good percentage elongation (9.4%), good folding endurance (120±4), and highest in vitro drug release of 99.39±5.28% within 9 min. In vivo studies showed significant improvement in pharmacokinetic parameters of Cmax, Tmax and AUC as compared with marketed product. The fast dissolving films of anti-Parkinson drugs were found to be a better option in the management of Parkinson’s disease by way of fast onset of action for patient convenience and compliance.

Key Words: Rasagiline, Parkinson’s disease, HPMC, fast dissolving oral films, Pharmacokinetic parameters.

 


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