American Journal of PharmTech Research

Pergularia daemia (Forssk.) Chiov., commonly known as Veliparuthi or Utranmul, is a perennial climbing herb belonging to the Asclepiadaceae family. This plant has been extensively used in traditional medicinal systems including Ayurveda, Unani, and Siddha for treating various ailments. This comprehensive review synthesizes current knowledge on the ethnobotanical uses, phytochemical composition, and pharmacological properties of P. daemia. The plant contains diverse bioactive compounds including alkaloids, flavonoids, glycosides, saponins, tannins, and steroids. Extensive pharmacological studies have demonstrated multiple therapeutic properties including antidiabetic, anti-inflammatory, antimicrobial, antioxidant, hepatoprotective, anticancer, wound healing, and immunomodulatory activities. This review critically evaluates the scientific evidence supporting traditional uses and discusses the molecular mechanisms underlying the observed pharmacological effects. Despite promising preclinical findings, clinical trials are needed to validate therapeutic efficacy and safety. This review provides a comprehensive foundation for future research aimed at developing evidence-based phytopharmaceuticals from P. daemia.

In the design of new bioactive compounds, the development of hybrid molecules through the combination of different pharmacophores in one frame may lead to compounds with interesting biological profiles. Serial of the “1-aryl-5-para-tolyl 2-s-benzyl-2-4-isodithiobiurets”was prepared by the interaction of 1-aryl-s-benzyl-isothiocarbamide and P-tolyl-isothiocynate in Benzene Medium. The Reaction was refluxed for 3-hours in benzene medium. After completion of the reaction, the solvent was distilled off and sticky residue obtained was triturated with petroleum ether (60-80oC) to afford a pale yellow solid (IIIa). It was purified by chloroform-petroleum ether (IIIa), m.p. 1700C. The elemental analysis of this new product indicated molecular formula as C22H21N3S2 Acylureas and biurets are noncyclic compounds which upon replacement of one or both oxygen with sulphur results into the formation of thiobiurets and dithiobiurets respectively. Isodithiobiuret derivatives shows potent biological activities such as anticonvulsant, hypnotic, analgesic, antifungal, insecticidal activity.

Gymnosporia senegalensis (Lam.) Loes., belonging to the family Celastraceae, is a shrub or small tree widely distributed across Africa and parts of Asia. Traditionally, the plant has been extensively utilized in folk and indigenous medical systems for the management of various ailments such as malaria, gastrointestinal disturbances, dermatological conditions, and pain-related disorders. The present review consolidates available scientific literature on the phytochemical composition and pharmacological properties of G. senegalensis, highlighting its therapeutic relevance. Phytochemical investigations have revealed the presence of bioactive compounds including tannins, flavonoids, alkaloids, and saponins, which are believed to play a key role in its medicinal effects. Experimental studies have demonstrated notable antimicrobial, anti-inflammatory, antioxidant, and cytotoxic activities associated with different parts of the plant. These findings suggest that G. senegalensis holds considerable promise as a source of bioactive compounds, warranting further systematic research to explore its potential in drug discovery and therapeutic development. Key words: Gymnosporia senegalensis, Medicinal Properties, Phytochemistry, Pharmacological Review.